Polynucleotides Contraindications & After Care

CONTRAINDICATIONS

Absolute Contraindications

• Allergy to fish or seafood (especially salmon/trout)

• Pregnancy or breastfeeding

• Active skin infection in treatment area

• Active herpes simplex (cold sores)

• Known hypersensitivity to any product ingredient

• Autoimmune disease affecting connective tissue (unless medically cleared)

• Active cancer or undergoing chemotherapy/radiotherapy

• History of anaphylaxis

• Severe uncontrolled diabetes

• Bleeding disorders

• Current anticoagulant therapy (unless medically approved)

Relative Contraindications (Require Clinical Assessment)

• Previous dermal filler in the same area (within 4–6 weeks)

• Recent laser, peel or microneedling (within 2–4 weeks)

• Immunosuppression

• Tendency toward keloid or hypertrophic scarring

• Recent vaccination (within 2 weeks)

• Active inflammatory skin conditions (eczema, psoriasis flare, dermatitis)

PRE-TREATMENT ADVICE

• Avoid alcohol 24–48 hours before treatment.

• Avoid aspirin, ibuprofen and blood-thinning supplements (omega 3, vitamin E, turmeric, ginkgo) for 3–5 days if medically safe.

• Do not have dental work 2 weeks before or after treatment.

• Avoid active skincare (retinol, acids, exfoliants) 3–5 days prior.

• Avoid intense sun exposure for 1–2 weeks prior.

• If prone to cold sores (especially peri-oral treatment), antiviral prophylaxis may be required.

• Attend appointment makeup-free where possible.

AFTERCARE ADVICE

Polynucleotides are regenerative treatments — visible swelling can be more pronounced than standard skin boosters.

Immediate Aftercare

• Expect redness, swelling and small raised blebs at injection points for 24–72 hours.

• Mild bruising is common.

• Tenderness in treated area may last several days.

First 24–48 Hours

• Do not massage the area unless instructed.

• Avoid makeup for 12–24 hours.

• Avoid heat: no sauna, steam, hot baths or intense exercise.

• Avoid alcohol.

• Do not apply active skincare.

First 7 Days

• Avoid facials, microneedling, laser or peels.

• Avoid excessive sun exposure.

• Use gentle cleanser and moisturiser only.

• Apply SPF 30–50 daily.

Expected Treatment Response

• Swelling may be more noticeable under the eyes or in thin skin areas.

• Mild lumpiness may be felt temporarily as product integrates.

• Skin quality improvement develops gradually over 3–6 weeks.

• A course of 2–3 treatments spaced 2–4 weeks apart is typically recommended.

• Full collagen remodelling continues for up to 12 weeks.